Genetic Approaches To

Complex Heart, Lung, and Blood Diseases

 

September 23 – October 2, 2005

(Evening registration September 23rd)

 

 

Schedule

                     

                For more information please contact:  Nancy.Place@jax.org

 

Friday, September 23rd

Evening Registration

 

 

4:00-7:00                    Registration and Dinner Buffet

 

7:00-7:30                    Molecular Biology Tutorial- Understanding PCR  (optional)

Greg Hawkins, Ph.D., Wake Forest University

 

 

 

Saturday, September 24th

Establishing the Foundations

All lectures and workshops are on the 3rd floor at Highseas unless otherwise noted

 

 

7:30-8:30 a.m.                        Breakfast

 

8:30-8:45                    Welcome and Announcements

                                    Beverly Paigen, Ph.D., The Jackson Laboratory

                                   

8:45 -10:15                 Introduction to Molecular Genetics

Greg Hawkins, Ph.D., Wake Forest University

 

10:15-10:30                Break (Dining Room)

 

10:30-10:45                Course evaluation

                                    Suzanne Hart, University of Maine

 

10:45-12:15pm                       Introduction to Human Genetics: Approaches in Mendelian Genetics

Deborah Meyers Ph.D., Wake Forest University

 

12:15-1:15                  Lunch

 

1:15 - 2:15                  The Power of Human Genetics

Eugene Bleecker M.D., Wake Forest University

 

2:15-3:30                    Using Mouse Genetics to Find Human Disease Genes

                                    Beverly Paigen, Ph.D., The Jackson Laboratory

 

3:30-6:00                    Free Time – Hike or Bike: Witch Hole Pond Carriage Road

                                    (Transportation and maps provided, bikes are reserved at the Bar Harbor Bike Shop nearby for those that registered ahead of time)

 

6:00-7:00                    Dinner

 

7:00-7:30                    Optional Tutorial: Reviewing today's unfamiliar terminology

 Greg Hawkins, Ph.D., Wake Forest University

                                     Beverly Paigen, Ph.D., The Jackson Laboratory

                                     Deborah Meyers, Wake Forest University

 

7:30-9:00                    Introductions - Students and Faculty – Gene Bleecker

                                    (Who am I, What disease I work on) Held in Highseas Living Room

 

 

 

Sunday, September 25th

Gene Mapping in Humans

All lectures and workshops are on the 3rd floor at Highseas unless otherwise noted

 

7:30-8:30 a.m.                        Breakfast

 

8:30-9:45                    Introduction to Linkage Analysis: Parametric and Non-parametric

Deborah Meyers Ph.D., Wake Forest University

 

9:45-10:00                  Break

 

10:00-11:15                Practical Approaches to Linkage Analysis

Jianfeng Xu MD, Dr.PH, Wake Forest University

 

11:15-12:00                Statistical Power in Linkage Studies

Deborah Meyers Ph.D., Wake Forest University

                                               

12:00-1:00 p.m.          Lunch

 

1:00-1:45                    Introduction to Association Studies (single SNP approaches)

Deborah Meyers Ph.D., Wake Forest University

 

1:45-3:15                    Introduction to Association Studies (multiple SNP approaches)

Jianfeng Xu MD, Dr.PH, Wake Forest University

 

 

 

 

3:15-4:00                    Study Design Workshop

                                    Eugene Bleecker and Deborah Meyers

 

4:00-6:00                    Free Time - (Shuttle runs will be provided downtown and back from Highseas until 6:35pm.)

                                                                       

6:00-7:00                    Dinner

 

 

 

Monday, September 26th

Genetic Epidemiology

All lectures and workshops are on the 3rd floor at Highseas unless otherwise noted

 

 

7:30-8:30 a.m.                        Breakfast

 

8:30-8:45                    Review

Deborah Meyers Ph.D., Wake Forest University

 

8:45-10:15                  Assessing Whether the Disease is Genetic

Terri Beaty Ph.D., Johns Hopkins University

           

10:15-10:30                Break             

 

10:30-11:30                Heritability Analysis in Twins and Families

Melissa Austin M.S., Ph.D., University of Washington

 

11:30-12:00 p.m.        Gene-environment Interactions 

Terri Beaty Ph.D., Johns Hopkins University

                                               

12:00-1:00 pm                        Lunch

 

1:00-2:15                    Gene-environment Interactions (continued)

Terri Beaty Ph.D., Johns Hopkins University

 

2:15-3:30                    Genetic Association Studies Using Family Data

Melissa Austin M.S., Ph.D., University of Washington

                                                 

3:30-6:00                    Free Time

                                    (Questions & Answers for todayÕs faculty in the Library from 3:30 – 4:30)

 

6:00-7:00                    Dinner

 

7:00-9:00                    Ethical, Legal, and Social Issues in Human Genetics Research

                                    A Case Study of the Native American Havasapai Tribe

Melissa Austin M.S., Ph.D., University of Washington

 

 

 

 

 

Tuesday, September 27th

 Gene Mapping in Humans,

Computer Resources

All lectures and workshops are on the 3rd floor at Higheas unless otherwise noted

           

 

7:30-8:30 a.m.                        Breakfast

 

8:30-8:45                    Review

Melissa Austin M.S., Ph.D., University of Washington

 

8:45-9:45                    Workshop in Identifying QTL Genes: Illustrations from papers using 3 approaches: candidate gene, pathway analysis, positional cloning

                                    Gene Bleecker, Jianfeng Xu, Deborah Meyers

 

9:45-10:00                  Break - Group Photo, weather permitting

 

10:00-12:00                Workshop, cont.        

                                    Gene Bleecker, Jianfeng Xu, Deborah Meyers

                                               

12:00-1:00                  Lunch

 

1:00-2:00                    Introduction to Sequence Databases                         

                                    Donna Maglott, Ph.D., National Center for Biotechnology Information                                                                                                                      

2:00-2:30                    Maps and Map Resources

                                    Donna Maglott, Ph.D., National Center for Biotechnology Information

 

2:30-4:15                    Computer Workshop –

¤       Groups A & B: Hike – Great Head

¤       Groups C & D: Computer Workshop

4:45-6:30                    Computer Workshop –

¤       Groups A & B: Computer Workshop

¤       Groups C & D: Hike – Great Head

                                    David Shaw, The Jackson Laboratory and Donna Maglott

                                   

                                   

Group A

Group B

Group C

Group D

Arrunda Olson

He

Mohsenin

Ramadas

Bailey

Hsu

Mora

Ryan

Baldwin

Imomorin

Mourani

Sadeghnejad

Bray

Kavaslar

Olson

Seshadri

DÕAgostino

Khera

Ordonez

Suk Danik

Denlinger

Kraft

Ouzounian

Sumino

Friel

Li

Palaniappan

Szatkiewicz

Grover

Lum

Peters

Thomas

Gupta

 

Piavaux

 

 

 

6:30-7:30                    Dinner

 

7:30-9:30                    Computer workshops

                                    David Shaw and Donna Maglott

 

 

 

Wednesday, September 28th

Complex trait mapping in animal models

All lectures and workshops are on the 3rd floor at Highseas unless otherwise noted

 

 

7:30-8:30 a.m.                        Breakfast

 

8:30-8:45                    Review

Deborah Meyers Ph.D., Wake Forest University

 

8:45-9:45                    Basic Mouse Genetics

Beverly Paigen, Ph.D., The Jackson Laboratory

 

9:45-10:00                  Break  (back up day for group photo)

 

10:00-11:00                QTL Mapping in the Mouse and Narrowing QTL with Genetics

                                    Beverly Paigen, Ph.D., The Jackson Laboratory

 

11:00-12:00                Sleep Disorders

                                    Allan Pack M.B.,Ch.B., Ph.D., University of Pennsylvania

 

12:00-1:00 p.m.          Lunch  (Faculty Meeting/Luncheon) Highseas Library

 

1:00-2:00                    Complex Trait Analysis:

 

Prospects for a Predictive Genetics

                                    Gary Churchill, Ph.D., The Jackson Laboratory

 

2:00-3:00                    Review and questions:  QTL mapping in animal models

                                    Bev Paigen

 

3:00-9:00 p.m.                        at Bev PaigenÕs Cottage, Long Pond- transportation provided 

                                   

                                    3-6  Free time- Kayaks provided: sign-ups available at Registration

6-7  Dinner

                                    7-9 Discussion of papers at by faculty: examples of finding genes.  

           

 

 

 

 

 

 

 

 

 

Thursday, September 29th

Finding and Characterizing the QTL Gene

All lectures and workshops are on the 3rd floor at Highseas unless otherwise noted

 

 

7:30-8:30 a.m.                        Breakfast

 

8:30-8:45                    Review

                                    Beverly Paigen, Ph.D., The Jackson Laboratory

 

8:45-9:45                    Bioinformatic Toolbox for Narrowing QTL

                                    Beverly Paigen, Ph.D., The Jackson Laboratory

                       

9:45-10:00                  Break

 

10:00-11:00                Physical Mapping and Evaluating Candidate Genes

Joachim Herz MD, University of Texas, Southwestern

 

11:00-12:00                Constructing Animal Models - Transgenics and Knockouts

                                    Joachim Herz MD, University of Texas, Southwestern

                                                                       

12:00-1:00                  Lunch - TJL staff members invited at participants request

 

1:00-2:15                    In Vitro Analysis of Gene Function

Joachim Herz MD, University of Texas, Southwestern

 

2:30 - 6:00                  Free Time/Lab Tour Or Hike Along Park Loop Road

                                    (Transportation provided)

 

6:00-7:00                    Lobster Dinner 

                                   

 

 

 

                       

Friday, September 30th

Expression Studies

All lectures and workshops are on the 3rd floor at Highseas unless otherwise noted

 

 

7:30-8:30 a.m.                        Breakfast

 

8:30-8:45                    Review

Joachim Herz MD, University of Texas, Southwestern

 

8:45-9:45                    Experimental Design for Spotted cDNA Microarrays

                                    Gary Churchill, Ph.D., The Jackson Laboratory

                                   

9:45-10:00                  Break

 

 

10:00-11:00                Using Microarrays in Complex Trait Analysis

 

                                    Naftali Kaminski, M.D., University of Pittsburgh Medical Center                    

 

11:00-12:00                EST-based Transcriptome Maps and Global Expression Assays

                                    Derry Roopenian, Ph.D., The Jackson Laboratory

 

12:00-1:00 p.m.          Lunch

 

1:00-3:00                    Workship on Microarrays: practical approaches and problem solving

                                    Naftali Kaminski, M.D., University of Pittsburgh Medical Center

                                   

3:00-6:00                    Free Time

                                    Transportation available, see message board for shuttle schedule.

 

6:00-7:00                    Dinner

 

7:00-9:00                    Students present Grant Proposals

 

 

 

Saturday, October 1st

Gene Characterization

All lectures and workshops are on the 3rd floor at Highseas unless otherwise noted

 

 

7:30-8:30 a.m.                        Breakfast

 

8:30-9:30                    Chemical Mutagenesis – Making New Mutants         

                                    Karen Svenson, The Jackson Laboratory

 

9:30-10:30                  Asthma In Humans

                                    Eugene Bleecker M.D., Wake Forest University

 

10:30-10:45                Break

 

10:45-12:00                CD14 as a model for gene-environment interaction

                                    Donata Vercelli, M.D., University of Arizona

 

12:00-1:00                  Lunch

 

1:00-2:00                    Pharmacogenetics

Eugene Bleecker, M.D., Wake Forest University

 

2:00-3:00                    Functional Characterization of a Gene: IL13 as an example

                                    Donata Vercelli, M.D., University of Arizona

                                                                       

3:00-6:00                    Free Time

                                    (Transportation Provided – See Shuttle Schedule)

 

6:00                             Dinner

 

 

Sunday, October 2nd

 

 

7:30-8:30                    Breakfast

 

 

End of Course!