Genetic Approaches
To
Complex Heart, Lung,
and Blood Diseases
September 23 –
October 2, 2005
(Evening
registration September 23rd)
Schedule
Friday, September
23rd
Evening Registration
4:00-7:00
Registration
and Dinner Buffet
7:00-7:30
Molecular
Biology Tutorial- Understanding PCR
(optional)
Greg Hawkins, Ph.D., Wake Forest University
Saturday, September
24th
Establishing the
Foundations
All lectures and
workshops are on the 3rd floor at Highseas unless otherwise
noted
7:30-8:30 a.m.
Breakfast
8:30-8:45
Welcome
and Announcements
Beverly
Paigen, Ph.D., The Jackson Laboratory
8:45 -10:15
Introduction
to Molecular Genetics
Greg Hawkins, Ph.D., Wake Forest University
10:15-10:30
Break
(Dining Room)
10:30-10:45
Course
evaluation
Suzanne
Hart, University of Maine
10:45-12:15pm
Introduction
to Human Genetics: Approaches in Mendelian Genetics
Deborah Meyers Ph.D., Wake Forest University
12:15-1:15
Lunch
1:15 - 2:15
The
Power of Human Genetics
Eugene Bleecker M.D., Wake Forest University
2:15-3:30
Using
Mouse Genetics to Find Human Disease Genes
Beverly Paigen, Ph.D.,
The Jackson Laboratory
3:30-6:00
Free
Time – Hike or Bike: Witch Hole Pond Carriage Road
(Transportation
and maps provided, bikes are reserved at the Bar Harbor Bike Shop
nearby for
those that registered ahead of time)
6:00-7:00
Dinner
7:00-7:30
Optional
Tutorial: Reviewing today's unfamiliar terminology
Greg Hawkins, Ph.D.,
Wake Forest University
Beverly
Paigen, Ph.D., The Jackson Laboratory
Deborah Meyers, Wake Forest
University
7:30-9:00
Introductions
- Students and Faculty – Gene Bleecker
(Who
am I, What disease I work on) Held in Highseas Living Room
Sunday, September
25th
Gene Mapping in
Humans
All lectures and
workshops are on the 3rd floor at Highseas unless otherwise
noted
7:30-8:30 a.m.
Breakfast
8:30-9:45
Introduction
to Linkage Analysis: Parametric and Non-parametric
Deborah Meyers Ph.D., Wake Forest University
9:45-10:00
Break
10:00-11:15
Practical
Approaches to Linkage Analysis
Jianfeng Xu MD, Dr.PH, Wake Forest University
11:15-12:00
Statistical
Power in Linkage Studies
Deborah Meyers Ph.D., Wake Forest University
12:00-1:00 p.m.
Lunch
1:00-1:45
Introduction
to Association Studies (single SNP approaches)
Deborah Meyers Ph.D., Wake Forest University
1:45-3:15
Introduction
to Association Studies (multiple SNP approaches)
Jianfeng Xu MD, Dr.PH, Wake Forest University
3:15-4:00
Study
Design Workshop
Eugene
Bleecker and Deborah Meyers
4:00-6:00
Free
Time - (Shuttle runs will be
provided downtown
and back from Highseas until 6:35pm.)
6:00-7:00
Dinner
Monday, September
26th
Genetic Epidemiology
All lectures and
workshops are on the 3rd floor at Highseas unless otherwise
noted
7:30-8:30 a.m.
Breakfast
8:30-8:45
Review
Deborah Meyers Ph.D., Wake Forest University
8:45-10:15
Assessing
Whether the Disease is Genetic
Terri Beaty Ph.D., Johns Hopkins University
10:15-10:30
Break
10:30-11:30
Heritability
Analysis in Twins and Families
Melissa Austin M.S., Ph.D., University of
Washington
11:30-12:00 p.m.
Gene-environment
Interactions
Terri Beaty Ph.D., Johns Hopkins University
12:00-1:00 pm
Lunch
1:00-2:15
Gene-environment
Interactions (continued)
Terri Beaty Ph.D., Johns Hopkins University
2:15-3:30
Genetic
Association Studies Using Family Data
Melissa Austin M.S., Ph.D., University of
Washington
3:30-6:00
Free
Time
(Questions
& Answers for todayÕs faculty in the Library from 3:30 –
4:30)
6:00-7:00
Dinner
7:00-9:00
Ethical,
Legal, and Social Issues in Human Genetics Research
A
Case Study of the Native American Havasapai Tribe
Melissa Austin M.S., Ph.D., University of
Washington
Tuesday, September
27th
Gene
Mapping in Humans,
Computer Resources
All lectures and
workshops are on the 3rd floor at Higheas unless otherwise
noted
7:30-8:30 a.m.
Breakfast
8:30-8:45
Review
Melissa Austin M.S., Ph.D., University of
Washington
8:45-9:45
Workshop
in Identifying QTL Genes: Illustrations from papers using 3 approaches:
candidate gene, pathway analysis, positional cloning
Gene Bleecker,
Jianfeng
Xu, Deborah Meyers
9:45-10:00
Break
- Group Photo, weather permitting
10:00-12:00
Workshop,
cont.
Gene Bleecker,
Jianfeng
Xu, Deborah Meyers
12:00-1:00
Lunch
1:00-2:00
Introduction
to Sequence Databases
Donna
Maglott, Ph.D., National Center for Biotechnology Information
2:00-2:30
Maps
and Map Resources
Donna
Maglott, Ph.D., National Center for Biotechnology Information
2:30-4:15
Computer
Workshop –
¤
Groups A
& B:
Hike – Great Head
¤
Groups C
& D:
Computer Workshop
4:45-6:30
Computer
Workshop –
¤
Groups A
& B:
Computer Workshop
¤
Groups C
& D:
Hike – Great Head
David
Shaw, The Jackson Laboratory and Donna Maglott
Group A |
Group B |
Group C |
Group D |
Arrunda Olson |
He |
Mohsenin |
Ramadas |
Bailey |
Hsu |
Mora |
Ryan |
Baldwin |
Imomorin |
Mourani |
Sadeghnejad |
Bray |
Kavaslar |
Olson |
Seshadri |
DÕAgostino |
Khera |
Ordonez |
Suk Danik |
Denlinger |
Kraft |
Ouzounian |
Sumino |
Friel |
Li |
Palaniappan |
Szatkiewicz |
Grover |
Lum |
Peters |
Thomas |
Gupta |
|
Piavaux |
|
6:30-7:30
Dinner
7:30-9:30
Computer
workshops
David
Shaw and Donna Maglott
Wednesday, September
28th
Complex trait
mapping in animal models
All lectures and
workshops are on the 3rd floor at Highseas unless otherwise
noted
7:30-8:30 a.m.
Breakfast
8:30-8:45
Review
Deborah Meyers Ph.D., Wake Forest University
8:45-9:45
Basic
Mouse Genetics
Beverly Paigen, Ph.D., The Jackson Laboratory
9:45-10:00
Break (back up day for group photo)
10:00-11:00
QTL
Mapping in the Mouse and Narrowing QTL with Genetics
Beverly
Paigen, Ph.D., The Jackson Laboratory
11:00-12:00
Sleep
Disorders
Allan
Pack M.B.,Ch.B., Ph.D., University of Pennsylvania
12:00-1:00 p.m.
Lunch (Faculty Meeting/Luncheon) Highseas Library
1:00-2:00 Complex Trait Analysis:
Prospects for a Predictive Genetics
Gary Churchill, Ph.D.,
The Jackson Laboratory
2:00-3:00
Review
and questions: QTL mapping in
animal models
Bev
Paigen
3:00-9:00 p.m.
at
Bev PaigenÕs Cottage, Long Pond- transportation provided
3-6 Free time- Kayaks provided:
sign-ups
available at Registration
6-7
Dinner
7-9
Discussion of papers at by faculty: examples of finding genes.
Thursday, September
29th
Finding and
Characterizing the QTL Gene
All lectures and
workshops are on the 3rd floor at Highseas unless otherwise
noted
7:30-8:30 a.m.
Breakfast
8:30-8:45
Review
Beverly
Paigen, Ph.D., The Jackson Laboratory
8:45-9:45
Bioinformatic
Toolbox for Narrowing QTL
Beverly
Paigen, Ph.D., The Jackson Laboratory
9:45-10:00
Break
10:00-11:00
Physical
Mapping and Evaluating Candidate Genes
Joachim Herz MD, University of Texas,
Southwestern
11:00-12:00
Constructing
Animal Models - Transgenics and Knockouts
Joachim
Herz MD, University of Texas, Southwestern
12:00-1:00
Lunch
- TJL staff members invited at participants request
1:00-2:15
In
Vitro Analysis of Gene Function
Joachim Herz MD, University of Texas,
Southwestern
2:30 - 6:00
Free
Time/Lab Tour Or Hike Along
Park Loop Road
(Transportation
provided)
6:00-7:00
Lobster
Dinner
Friday, September
30th
Expression Studies
All lectures and
workshops are on the 3rd floor at Highseas unless otherwise
noted
7:30-8:30 a.m.
Breakfast
8:30-8:45
Review
Joachim Herz MD, University of Texas,
Southwestern
8:45-9:45
Experimental
Design for Spotted cDNA Microarrays
Gary
Churchill, Ph.D., The Jackson Laboratory
9:45-10:00
Break
10:00-11:00 Using Microarrays in Complex Trait Analysis
Naftali
Kaminski, M.D., University of Pittsburgh Medical Center
11:00-12:00
EST-based
Transcriptome Maps and
Global Expression Assays
Derry
Roopenian, Ph.D., The Jackson
Laboratory
12:00-1:00 p.m.
Lunch
1:00-3:00
Workship
on Microarrays: practical approaches and problem solving
Naftali Kaminski,
M.D., University of Pittsburgh
Medical Center
3:00-6:00
Free
Time
Transportation
available, see message board for
shuttle schedule.
6:00-7:00
Dinner
7:00-9:00
Students
present Grant Proposals
Saturday, October
1st
Gene
Characterization
All lectures and
workshops are on the 3rd floor at Highseas unless otherwise
noted
7:30-8:30 a.m.
Breakfast
8:30-9:30
Chemical
Mutagenesis – Making New Mutants
Karen
Svenson, The Jackson Laboratory
9:30-10:30
Asthma In Humans
Eugene Bleecker M.D.,
Wake Forest University
10:30-10:45
Break
10:45-12:00
CD14
as a model for gene-environment interaction
Donata
Vercelli, M.D., University of Arizona
12:00-1:00
Lunch
1:00-2:00
Pharmacogenetics
Eugene Bleecker, M.D., Wake Forest University
2:00-3:00
Functional
Characterization of a Gene: IL13 as an example
Donata
Vercelli, M.D., University of
Arizona
3:00-6:00
Free
Time
(Transportation
Provided – See Shuttle Schedule)
6:00
Dinner
Sunday, October 2nd
7:30-8:30
Breakfast